Concentration-time response relationships are of interest in estimating the hazards for the population living close to pressurised storage tanks of industrial gases in case of failure of containments. So an Excel application was developed, which will estimate concentration- time response relationships from the raw observations in animal acute inhalation toxicity studies. This Excel application replaces the former DoseResp.exe program.

This Excel application is an easy tool to analyse quantal data. The analysis allows for:

• selection of trials from a large dataset.
• data transformation.
• selection of probit, weibull or toxicokinetic model.
• numerical analysis of data including estimation of dose parameters at specified response.
• free source code.

References

Berge WF ten, 1985. The toxicity of methylisocyanate for rats. Journal of Hazardous Materials vol.12 [n3],pg:309-311,1985

Berge WF ten; Zwart A; Appelman LM, 1986. Concentration-time mortality response relationship of irritant and systemically acting vapors and gases. Journal of Hazardous Materials vol.13 [n3],pg:301- 309,1986

Berge WF ten; Zwart A; 1989. More efficient use of animals in acute inhalation toxicity testing. Journal of Hazardous Materials vol.21 [n1],pg:65-71,1989

Finney DJ, 1977. Probit Analysis. Cambridge University Press.

Download the latest version of DoseRespBeta2006

You can download the Excel application and Manual from the zipfile (doserespx.zip)

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